منابع مشابه
PairsDB atlas of protein sequence space
Sequence similarity/database searching is a cornerstone of molecular biology. PairsDB is a database intended to make exploring protein sequences and their similarity relationships quick and easy. Behind PairsDB is a comprehensive collection of protein sequences and BLAST and PSI-BLAST alignments between them. Instead of running BLAST or PSI-BLAST individually on each request, results are retrie...
متن کاملPercolation in protein sequence space
The currently known protein sequences are not distributed equally in sequence space, but cluster into families. Analyzing the cluster size distribution gives a glimpse of the large and unknown extant protein sequence space, which has been explored during evolution. For six protein superfamilies with different fold and function, the cluster size distributions followed a power law with slopes bet...
متن کاملA Voyage through Protein Sequence Space
The search for novel proteins is complicated by the diversity of amino acids, the non-linear relationship between amino acid sequence and folding and the huge size of sequence space. The goal of this research is to discover patterns in amino acid composition and sequence that relate to known or novel folds, thereby helping to constrain the search space for new functional proteins. This approach...
متن کاملA new sequence space and norm of certain matrix operators on this space
In the present paper, we introduce the sequence space [{l_p}(E,Delta) = left{ x = (x_n)_{n = 1}^infty : sum_{n = 1}^infty left| sum_{j in {E_n}} x_j - sum_{j in E_{n + 1}} x_jright| ^p < infty right},] where $E=(E_n)$ is a partition of finite subsets of the positive integers and $pge 1$. We investigate its topological properties and inclusion relations. Moreover, we consider the problem of fin...
متن کاملFrom protein sequence space to elementary protein modules.
The formatted protein sequence space is built from identical size fragments of prokaryotic proteins (112 complete proteomes). Connecting sequence-wise similar fragments (points in the space) results in the formation of numerous networks, that combine sometimes different types of proteins sharing, though, fragments with similar or distantly related sequences. The networks are mapped on individua...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2007
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkm879